It is safe provided you use it as directed, but you might find other creams work better.
The backs of my hands went mental when I was first pregnant and it only got worse until it more or less looked like I was wearing fingerless gloves. My doctor prescribed that for me and said it'd be fine, so I used it but not very often and not very much at a time. I've actually found using the body butter I use on my tummy has made it better when the prescribed cream did nothing at all