Downs Syndrome

Does anyone know if its possible to have a baby with a mild form of downs, even when an amniocentesis in pregnancy was negative?
My neice has always has a strange shaped, large head. She has a big forehead and sukken eyes, and flat bridge of her nose. Plus odd shaped toes. She is 10 months odl, and meeting developmental milestones.
But when I saw an article in a mag about twins with Downs, I was astounded how similar they look to my neice. Plus a friend on neices mum asked another of her friends if my niece had Downs, because she said she looked like she did.

TIA

If she's meeting her milestones, I'd be surprised if its DS, and amnio is very accurate. However, there are lots of syndromes out there, most of which aren't screened for on amnio. If there are concerns, ask the GP for a referral to a developmental pediatrician

Oh cool thanks for that Flissty.

I knew a little girl a few years ago who I would have sworn was downs, but she wasn't. She'd been through a number of tests because she really had that clasic downs face, but no. Not downs. Which, in theory, means that it may just be a normal facial type. Do you know what I mean?

I have friends with a Downs child, and as Flissty said - if she's meeting her milestones, it would be unusual if she was Downs.

Amnio is 100% acurate so if it was negative for DS, then she won't have it.

I can't for the life of me remember where it was, maybe another forum that I dropped in to once, but there was a young woman who had a little girl who was not diagnosed with Downs until she was about 10 months old. To look at her, she looked *slightly* like a Downs child, but was meeting all the developmental milestones and it wasn't until they discovered a heart issue that she was diagnosed.